<span>Agricultural soils are the dominant source of anthropogenic N₂O emissions, yet their high spatial and temporal heterogeneity provides a major challenge for accurately quantifying emissions and evaluating mitigation options. Most national greenhouse gas inventories rely on empirical Tier-1 or Tier-2 emission-factor approaches and therefore do not fully capture the effects of climate variability, soil properties, or management practices. Here, we present a transferable, process-based modelling framework based on the biogeochemical model LandscapeDNDC for determining direct and indirect N₂O emissions from major crops cultivated on mineral soils at the national scale. We apply the method to Germany making use of high-resolution input data provided by the national reporting agencies, estimating N₂O emissions of 35 (29&ndash;44) kt N yr^-1(2017&ndash;2022 average). This is 28 % higher than the national inventory report (submission 2025), but well within the uncertainty range. In contrast to conventional inventory methods, the framework explicitly accounts for interannual climate variability and can be spatially disaggregated at high resolution, taking into account local variations in soil type, weather and agricultural management practices. Because the model simulates coupled carbon and nitrogen cycling, it also quantifies multiple nitrogen loss pathways and potential changes in carbon stocks simultaneously, providing a consistent basis for evaluating mitigation strategies and their potential trade-offs. Our results demonstrate that process-based modelling can substantially improve the spatial and temporal resolution of agricultural N₂O emissions and provide a platform for developing next-generation national greenhouse gas inventories. While further work is required before the framework fully satisfies all IPCC Tier-3 requirements, it offers a pathway towards a more mechanistic and policy-relevant assessment of agricultural greenhouse gas emissions. </span><span></span>