How aerosol physicochemical properties affect aerosol-cloud interactions (ACI) and when these impacts are most pronounced represent an important source of ACI uncertainty. Targeting a representative liquid-phase cloud case over the Eastern China Ocean (ECO) under the winter monsoon featuring abundant meteorological, aerosol, and cloud variations, this study investigates the impacts of changes in aerosol size (volume-mean radius increased by 1.2 times and decreased by 45 %) and hygroscopicity (volume-mean hygroscopicity increased by 2.2 times and decreased by 62 %) using a spectral-bin cloud model. Results indicate that increased aerosol size and hygroscopicity generally enhance cloud development, raising the ECO-averaged cloud droplet number concentration (N<sub>d</sub>) by 92 % and 53 %, respectively. These impacts peak under moderate aerosol concentrations (N<sub>a</sub>) and cold advection, where N<sub>d</sub> increases up to 10-fold. Concurrently, increased aerosol size raises cloud water by 1.3 times and extends cloud lifetime by 85 %, whereas increased hygroscopicity has a much weaker effect. By contrast, decreased aerosol size and hygroscopicity generally suppress cloud development, reducing the ECO-averaged N<sub>d</sub> by 49 % and 43 %, respectively. The former has a relatively strong impact, which is most notable in moderate-to-high N<sub>a</sub> environments under cold advection, reducing N<sub>d</sub> and cloud water by over 80 % and 50 %, respectively. While changes in aerosol size generally exert a stronger overall impact than changes in hygroscopicity, specific conditions reveal the opposite. Notably, the enhancement of N<sub>d</sub> by increased hygroscopicity under high N<sub>a</sub>, and the preservation of cloud and rainwater through evaporation suppression by decreased hygroscopicity, both surpass the effects caused by corresponding aerosol size changes.