We present a new limited-area version of the aerosol–climate modeling system ICON coupled to HAM-lite. This new version is capable of simulating anthropogenic and natural aerosols and their climate effects in specific target regions. We demonstrate its flexibility and applicability through three case studies covering distinct aerosol regimes and processes: air pollution episodes in Central Europe, the emission and transport of sea salt aerosol in the Altantic Arctic, and the simultaneous formation of smoke and desert dust plumes during the 2019–2020 Australian bushfire season. These case studies show the ability of the model to capture the regional-scale patterns and diurnal variability of the predominant aerosol types. They also indicate, however, systematic biases related to the simplified representation of aerosol emission, microphysics, and chemistry. The insights that we gained from these regional simulations will guide future developments of HAM-lite.