Air stagnation occurs when weak horizontal ventilation and limited vertical mixing inhibit renewal of the lower atmosphere, allowing heat and pollutants to accumulate within the boundary layer. Despite the climatic and demographic importance of the Nile Delta, the long-term behavior of stagnation across this densely populated Mediterranean–continental transition zone remains poorly documented. This study provides the first multi-decadal assessment of stagnation dynamics over the Nile Delta during 1980–2020 using ERA5 reanalysis data at 0.25° × 0.25° spatial resolution. Stagnation days were identified using the Air Stagnation Index defined by thresholds of near-surface wind speed (U₁₀ < 3.2 m s⁻¹), 500-hPa wind speed (< 13 m s⁻¹), and daily precipitation below 1 mm. ERA5 fields were evaluated against regional meteorological observations, showing strong agreement in wind speed and precipitation variability and confirming the suitability of ERA5 for stagnation diagnostics. The results reveal a pronounced coastal–inland gradient in stagnation frequency. Annual means exceed 150 days in the southern sector (Cairo) and about 135 days in the central Delta (Tanta), whereas coastal locations such as Alexandria experience roughly 30 days per year. Air stagnation frequency increased significantly by about 0.7 day per decade during 1980–2020, with stronger trends inland. Stagnation frequency shows a strong inverse relationship with near-surface wind speed (r = −0.84), indicating that horizontal ventilation appears to exert a primary dynamical control on stagnation variability across the Delta. These findings identify the Nile Delta as one of the most stagnation-prone non-orographic coastal plains in the eastern Mediterranean.