Since the 1990s, satellite observations have been providing reliable estimates of ocean surface states, including absolute dynamic topography (ADT), sea surface temperature (SST), and sea surface salinity (SSS) at sufficient space and time scales to characterize ocean dynamics.  Together with the extensive hydrographic dataset from Argo and ship-based hydrographic profiles, these measurements provide a comprehensive view of oceanic conditions.  While ADT represents integrated information for subsurface water properties, it is challenging to relate SST, SSS, and ADT with subsurface water profiles due to their complex spatial and temporal variations. To address this issue, we introduce a novel deep neural network, the thermohaline profile estimating network termed TS-Cast. Sourcing from monthly climatological profiles, TS-Cast is designed to adjust these profiles to align with satellite-measured SST, SSS, and ADT data, by training with approximately 150,000 Argo and ship-based thermohaline profiles in the northwestern Pacific. TS-Cast’s capability is demonstrated by comparisons with independent time-series data from moorings that measured temperature and salinity or vertical acoustic travel time. The network significantly improves upon the climatological baseline, achieving an overall Root Mean Square Error (RMSE) of < 1 °C for temperature and < 0.1 psu for salinity in the upper 500-m depths at the Kuroshio Extension region. This performance surpasses that of data-assimilated numerical models and is comparable to that of a data-assimilated statistical model, validating TS-Cast as a powerful tool for ocean monitoring. Critically, this framework reveals not only TS-Cast's high fidelity but also demonstrates that the limitations of the input satellite data fundamentally constrain its predictive skill.