The increasing release of Antarctic meltwater represents one of the most profound, yet uncertain, consequences of global climate change. The absence of interactive ice sheets in state-of-the-art climate models prevents the direct calculation of ice-ocean feedbacks, leaving significant uncertainty in the global and regional consequences of meltwater discharge. This study leverages results from the Southern Ocean Freshwater Input from Antarctica (SOFIA) initiative to assess the ocean response to a 0.1 Sv meltwater perturbation and to infer the resulting feedback on ice shelf basal melting across 10 CMIP6 models. We analyze meltwater-induced temperature anomalies across distinct continental shelf regimes, compare them with SSP5-8.5 global warming-induced anomalies, and translate these into basal melt rates using a parameterization calibrated with a new observational climatology. Although the meltwater feedback is generally thought to amplify basal melting, our results demonstrate large regional differences, with implied enhanced ice shelf mass loss in some sectors but suppressed basal melting in others. The model ensemble indicates a warming feedback on the continental shelf in most East Antarctic regions, whereas in West Antarctica, the region with the greatest observed ice shelf mass loss in recent decades, most models simulate cooling or reduced warming, suggesting a negative feedback. This regional contrast implies that East Antarctica may play an increasingly dominant role in future ice shelf mass loss. Simulations support existing hypotheses linking these asymmetric temperature responses to strong regional connectivity and shelf break dynamics, including a strengthened Antarctic Slope Front, an accelerated Antarctic Slope Current, and reduced dense shelf water formation.