Past temperature reconstructions offer valuable insights into the impact of climate change on the global climate-human-vegetation system. Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are recognized as effective temperature proxies, particularly in lakes and peatlands, where they are well preserved. However, their reliability as palaeothermometers can be compromised by factors beyond air temperature, especially in drylands. This study introduces the Arid Central Asian (ACA) brGDGT surface Data Base, a regional dataset consisting of 162 new surface samples from the drylands of ACA, in addition to 599 previously published samples. The distribution of brGDGTs in relation to climate and environmental variables was analysed to explore their potential as reliable temperature proxies, mainly focusing on brGDGTs methylation (MBT), cyclisation (CBT), and isomer (IR) indices. The brGDGT-based palaeothermometer is a promising tool for understanding past climates, but our comparison between an ACA-centred database and a worldwide continental surface sample database reveals several challenges. Drylands exhibit extreme climate and soil/lacustrine properties, amplifying the impact of confounding factors on brGDGT-based relationships with mean annual air temperature. Salinity emerges as the dominant factor influencing brGDGT variance, followed by sample type, salinity, pH, and aridity, all of which contribute significantly. These factors interact in complex ways, with the salinity effect varying between soil and lacustrine deposits. For sample physicochemical conditions, the IR'_6+7Me index is best for salinity, and IR_6Me is most suitable for pH reconstruction. Despite this, the MBT'_5Me-temperature relationship is limited in ACA, particularly for lacustrine samples, and MBT'_6Me does not offer a better solution under hyper- to semi-arid conditions. Sub-calibrating models for specific environmental conditions such as salinity and aridity improves the accuracy of temperature reconstructions. Furthermore, the difference between MBT'_5Me and MBT'_6Me provides a promising proxy to assess aridity. Although the brGDGT signal in drylands is influenced by multiple confounding factors, it remains a valuable tool for understanding past climate and environmental conditions, especially when accounting for the complex interactions between these factors based on each study's unique physicochemical and bioclimatic context. Further research, incorporating a broader range of surface samples alongside comprehensive soil and climate data, holds the potential to enhance the accuracy of brGDGT-based climate reconstructions.