To improve hydrological uncertainty estimation, recent studies have explored machine learning (ML)-based post-processing approaches that enable both enhanced predictive performance and hydrologically informed probabilistic streamflow predictions. Among these, random forests (RF) and their probabilistic extension, quantile random forests (QRF), are increasingly used for their balance between interpretability and performance. However, the application of QRF in regional post-processing settings remains unexplored. In this study, we develop a hydrologically informed QRF post-processor trained in a multi-site setting and compare its performance against a locally (at-site) trained QRF using probabilistic evaluation metrics. The QRF framework leverages simulations and state variables from the GR6J hydrological model, along with readily available catchment descriptors, to predict daily streamflow uncertainty. Our results show that the regional QRF approach is beneficial for hydrological uncertainty estimation, particularly in catchments where local information is insufficient. The findings highlight that multi-site learning enables effective information transfer across hydrologically similar catchments and is especially advantageous for high-flow events. However, the selection of appropriate catchment descriptors is critical to achieving these benefits.