Northern landscapes are enduring ongoing impacts of anthropogenic land use and climate change. Rivers are valuable indicators of this change reflected by the timing and amount of water and terrestrial material they mobilize. Assessing the influence of a changing climate on diverse river systems is best achieved using multi-annual monitoring and replication of effort across varied tributary catchment conditions. We used this approach to monitor concentrations, catchment yields, and export of total suspended sediments (TSS) and dissolved organic carbon (DOC) of a large, diverse, glacial river network (North Saskatchewan River; NSR) in western Canada during years of extensive weather fluctuations. Though concentrations of TSS and DOC increased eastward through the NSR basin from Rocky Mountain cordillera to agriculturalized plains, catchment yields were statistically highest from cordillera regions, reflecting an eastward rain shadow. Wet conditions across the basin resulted in variable but statistically higher TSS and DOC yields compared to drought conditions. During higher water, we observed disordered, threshold-type, erosive mobilization of TSS through the basin whereas DOC increased more predictably with runoff. Variability of yields and export was substantial both within and between pristine and impacted catchments, and within the NSR mainstem illustrating the complexity of river sediment and organic matter transport at the network scale. Consequently, in a warming and wetting climate, we expect TSS and DOC transport to intensify with sediment transport being more difficult to predict compared to organic matter, which has implications for aquatic ecosystems and >1.5 M people who depend on the NSR for drinking water.